In addition to the "wrap-around effect" of the instrument panel support, the newly-designed multifunction steering wheel in the 3-spoke design in Nappa leather is particularly eye-catching. The steering wheel is available in black or almond beige; a wood-and-leather finish is also available as an optional extra. In the optional AMG Sports package there is a particularly sporty steering wheel which has a flattened wreath in the lower half. Both steering wheel options have 12 multifunction keys to control the infotainment functions.

The highlight of the exclusive CLS instrumentation is the all-colour, three-dimensional TFT display in the middle of the speedometer, measuring 109 millimetres in diameter. The mileage and trip odometer appear in the lower area of the display, the top displays - amongst other things - information from the driver assistance systems. A three-dimensional image of the vehicle appears when getting into or out of the Mercedes-Benz CLS-Class.

Three tube-shaped round dials in the cockpit inform the driver of the coolant temperature and fuel tank level (on the left), speed (in the middle) and engine rpm (on the right). A large colour display in 16:9 format, elegantly integrated into the upper part of the instrument panel support, gives information on all the infotainment functions. The TFT display (Active Matrix Thin Film Transistor), which is backlit with LED lights, uses so-called IPS technology. IPS stands for "in-plane switching", which describes the shift direction of the liquid crystal. The benefit of this technology is that it displays high-contrast images which stay sharp outside the direct line of vision. Depending on the specification, two versions of this cutting-edge display are available: a 14.7 cm version for the Audio 20 and Audio 50 APS systems; and a high-resolution 17.7 cm variant for COMAND APS.

The centre console fits harmoniously with the shape and colour of the instrument panel. The control unit for the infotainment system and the optional car telephone can be found underneath the analogue clock and air vents. The push-button switches for seat heating, seat ventilation, the hazard warning lamps, rear window blind and other items of equipment ordered as options are arranged below this; they have been galvanised and are backlit. The large round control knobs for the automatic climate control, which is supplied as standard, are located in the lower part of the centre console. The controller in the tunnel trim serves as the central control element for the infotainment systems and provides a quick and easy starting point for navigating the well-organised menus controlling the systems.