For more than 50 years, the saloons in the Mercedes-Benz E-Class and their predecessors have been acknowledged as trendsetters in the safety field. The new saloon continues this tradition with an unrivalled combination of the very latest assistance and protection system whose concept and development are based on what actually happens during accidents. These technologies make the Mercedes-Benz E-Class an "intelligent partner"who can see, feel, react reflexively in critical situations and if necessary act independently to prevent accidents or mitigate their consequences. With this concept the new Mercedes model not only protects its own occupants, but also contributes decisively to the greater safety of other road users.

The new Mercedes-Benz E-Class is the first automobile in the world whose headlamps adapt to the traffic situation and respond automatically to avoid dazzling other drivers. The optional Adaptive Main Beam Assist uses a camera on the windscreen to recognise oncoming traffic and vehicles moving ahead, and controls the headlamps so that their beams do not reach the other vehicle. This achieves the best possible road illumination in a given situation. The range of the dipped headlamp beams can be extended from 65 to up to 300 metres. If the road ahead is clear, the system performs a gentle transition to high beam.

Mercedes-Benz offers this new system as a light & sight package that includes bi-xenon headlamps, the Intelligent Light System and LED daytime driving lights.

The Lane Safety package for the new Mercedes-Benz E-Class includes Blind Spot Assist familiar from the S-Class, and as a new development, Lane Keeping Assist which seeks to prevent the vehicle from leaving the road unintentionally. When the system recognises that the car is drifting from its lane, the driver is prompted to take countersteering action by brief but unmistakable vibrations of the steering wheel. The images from the windscreen camera are also used by the new, optionally available Speed Limit Assist , which recognises speed limit signs as the car passes them, then displays the relevant speed limit in the speedometer.

Night View Assist from the S-Class is now also available as an optional extra for the new Mercedes-Benz E-Class. Mercedes-Benz has improved this system with a special pedestrian detection function: as soon as Night View Assist Plus recognises pedestrians ahead of the car, they are highlighted in the onboard display to provide a greatly enhanced warning effect.