The E 200 CGI and E 250 CGI are equipped with the newly developed four-cylinder direct-injection engine with a displacement of 1.8 litres, turbocharging and variable intake and exhaust camshafts. The E 200 CGI (135 kW/184 hp) is equipped with a six-speed manual transmission and the ECOstart/stop function as standard, and consumes only 6.8 litres of premium petrol per 100 kilometres (combined NEDC consumption, provisional figure). This equates to 159 grams of CO2 per kilometre.

In the E 250 CGI (150 kW/204 hp), which has a five-speed automatic transmission as standard, maximum torque is now 310 newton metres, which represents an increase of more than 26 percent over the previous V6-engine. At the same time the NEDC fuel consumption is reduced by over 20 percent to 7.4 litres per 100 kilometres, equating to 175 grams of CO2 per kilometre (provisional figures).

As before, the E 350 CGI with direct petrol injection (215 kW/292 hp) and the top-of-the-line E 500 (285 kW/388 hp) are included in the range of engine variants in the new Mercedes-Benz E-Class. Detailed improvements have reduced the fuel consumption of these V6/V8 models by up to 0.6 litres per 100 kilometres. As a product from Mercedes-AMG, the new high-performance E 63 AMG develops 386 kW/525 hp.

The V6 and V8-models are equipped with a seven-speed automatic transmission and steering wheel selector lever as standard.

On request the V6 models E 350 CDI and E 350, as well as the eight-cylinder E 500, are available with latest-generation Mercedes all-wheel drive. This system distinguishes itself from previous all-wheel drive technology with greater efficiency, lower weight and more compact construction. These advantages produce noticeably better traction and fuel savings.